Foundations of B2B electronic contracting

Nowadays, flexible electronic cooperation paradigms are required for core business processes to meet the speed and flexibility requirements dictated by fast-changing markets. These paradigms should include the functionality to establish the formal business relationship required by the importance of these core processes. The business relationship should be established in an automated, electronic way in order to match the speed and flexibility requirements mentioned above. As such, it should considerably improve on the ineffectiveness and inefficiency of traditional contracting in this context. The result of the establishment should be a detailed electronic contract that contains a complete specification of the intended cooperation between organizations. Electronic contracts should contain a precise and unambiguous specification of the collaboration at both the conceptual and technological level. Existing commercial software solutions for business-to-business contracting provide low level of automation and concentrate solely on the automated management of the contract enactment. However, in the modern, dynamic, business settings, an econtracting system has to support high automation of the e-contract establishment, enactment, and management. In the thesis, the business, legal, and technological requirements for the development of a highly automated e-contracting system are investigated. Models that satisfy these requirements and that can be used as a foundation for the implementation of an electronic contracting system are defined. First, the thesis presents the business benefits introduced to companies by highly automated electronic contracting. Next, a data and process analysis of electronic contracting is presented. The specification of electronic contracts and the required process support for electronic contract establishment and enactment are investigated. The business benefits and data and process models defined in the thesis are validated on the basis of two business cases from on-line advertising, namely the cases of online advertising in "De Telegraaf" and "Google". Finally, the thesis presents a specification of the functionalities that must be provided by an e-contracting system. A conceptual reference architecture that can be used as a starting point in the design and implementation of an electronic contracting system is defined. The work in the thesis is conducted on the intersection of the scientific areas of conceptual information and process modeling and specification on the one hand and distributed information system architecture modeling on the other hand

A Process Framework for Designing Software Reference Architectures for Providing Tools as a Service

Product-Focused Software Process ImprovementSoftware Reference Architecture (SRA), which is a generic architecture solution for a specific type of software systems, provides foundation for the design of concrete architectures in terms of architecture design guidelines and architecture elements. The complexity and size of certain types of software systems need customized and systematic SRA design and evaluation methods. In this paper, we present a software Reference Architecture Design process Framework (RADeF) that can be used for analysis, design and evaluation of the SRA for provisioning of Tools as a Service as part of a cloud-enabled workSPACE (TSPACE). The framework is based on the state of the art results from literature and our experiences with designing software architectures for cloud-based systems. We have applied RADeF SRA design two types of TSPACE: software architecting TSPACE and software implementation TSPACE. The presented framework emphasizes on keeping the conceptual meta-model of the domain under investigation at the core of SRA design strategy and use it as a guiding tool for design, evaluation, implementation and evolution of the SRA. The framework also emphasizes to consider the nature of the tools to be provisioned and underlying cloud platforms to be used while designing SRA. The framework recommends adoption of the multi-faceted approach for evaluation of SRA and quantifiable measurement scheme to evaluate quality of the SRA. We foresee that RADeF can facilitate software architects and researchers during design, application and evaluation of a SRA and its instantiations into concrete software systems.Muhammad Aufeef Chauhan, Muhammad Ali Babar, and Christian W. Probs

B2B eContract Handling - A Survey of Projects, Papers and Standards

The rapid development of IT gives rise to changes in many industries and different spheres of life. It simplifies and speeds up processes and data processing. As a result, it changes the processes and the data involved in them. The area of commerce and contracting in particular undergoes similar changes. The new developments aim at speeding up, facilitating and globalizing the process of contracting. This inevitably leads to new contracting processes and changes the standard approach for contracting. This report presents a survey of the research, development, and standardization efforts in the area of business-to-business e-contracting. The report is divided into three parts. The first part presents a multi-dimensional contracting framework. The second part reviews current standardization processes and developments in the e-commerce field. The third part provides summaries and comments on a selected set of papers on e-contracting. Depending on their goals, focus and content, the papers are categorized in accordance with the contract cycle phases described in one of the dimensions of the contracting framework. Where appropriate, the content of the papers is related to the dimensions of the contracting framework. This report further provides an acronym list of the most common abbreviations in e-commerce terminology

Experimental and theoretical studies of sequence effects on the fluctuation and melting of short DNA molecules

Understanding the melting of short DNA sequences probes DNA at the scale of the genetic code and raises questions which are very different from those posed by very long sequences, which have been extensively studied. We investigate this problem by combining experiments and theory. A new experimental method allows us to make a mapping of the opening of the guanines along the sequence as a function of temperature. The results indicate that non-local effects may be important in DNA because an AT-rich region is able to influence the opening of a base pair which is about 10 base pairs away. An earlier mesoscopic model of DNA is modified to correctly describe the time scales associated to the opening of individual base pairs well below melting, and to properly take into account the sequence. Using this model to analyze some characteristic sequences for which detailed experimental data on the melting is available [Montrichok et al. 2003 Europhys. Lett. {\bf 62} 452], we show that we have to introduce non-local effects of AT-rich regions to get acceptable results. This brings a second indication that the influence of these highly fluctuating regions of DNA on their neighborhood can extend to some distance.Comment: To be published in J. Phys. Condensed Matte

A CNL for Contract-Oriented Diagrams

We present a first step towards a framework for defining and manipulating normative documents or contracts described as Contract-Oriented (C-O) Diagrams. These diagrams provide a visual representation for such texts, giving the possibility to express a signatory's obligations, permissions and prohibitions, with or without timing constraints, as well as the penalties resulting from the non-fulfilment of a contract. This work presents a CNL for verbalising C-O Diagrams, a web-based tool allowing editing in this CNL, and another for visualising and manipulating the diagrams interactively. We then show how these proof-of-concept tools can be used by applying them to a small example

Structure of One-Phase Free Boundaries in the Plane

We study classical solutions to the one-phase free boundary problem in which the free boundary consists of smooth curves and the components of the positive phase are simply connected. We characterize the way in which the curvature of the free boundary can tend to infinity. Indeed, if curvature tends to infinity, then two components of the free boundary are close, and the solution locally resembles an entire solution discovered by Hauswirth, Hélein, and Pacard, whose free boundary has the shape of a double hairpin. Our results are analogous to theorems of Colding and Minicozzi characterizing embedded minimal annuli, and a direct connection between our theorems and theirs can be made using a correspondence due to Traizet.National Science Foundation (U.S.) (Grant DMS-1069225

MORPHOLOGICAL AND RADIOMETRIC EVALUATION OF INTRAVASCULAR COAGULATION IN EXPERIMENTAL BURN AND ENDOTOXIC SHOCK

The authors performed comparative morphological and radiometric (with 131 J-fibrinogen) study of the severity and dynamics of intravascular coagulation (IС) during burn and endotoxic shock in white male Wis tar rats. An early (at the 15th min) high intensity of IС was established in lungs and adrenals but a late peak of IС (until the 24th hour) was found out in kidneys, intestine, liver and spleen. IС intensity reduced significantly at the end of the first hour. There was some discrepancy between 131 J-fibrinogen accumulation and density of microthrombi in different organs

Proteomes of Lactobacillus delbrueckii subsp. bulgaricus LBB.B5 Incubated in Milk at Optimal and Low Temperatures.

We identified the proteins synthesized by Lactobacillus delbrueckii subsp. bulgaricus strain LBB.B5 in laboratory culture medium (MRS) at 37°C and milk at 37 and 4°C. Cell-associated proteins were measured by gel-free, shotgun proteomics using high-performance liquid chromatography coupled with tandem mass spectrophotometry. A total of 635 proteins were recovered from all cultures, among which 72 proteins were milk associated (unique or significantly more abundant in milk). LBB.B5 responded to milk by increasing the production of proteins required for purine biosynthesis, carbohydrate metabolism (LacZ and ManM), energy metabolism (TpiA, PgK, Eno, SdhA, and GapN), amino acid synthesis (MetE, CysK, LBU0412, and AspC) and transport (GlnM and GlnP), and stress response (Trx, MsrA, MecA, and SmpB). The requirement for purines was confirmed by the significantly improved cell yields of L. delbrueckii subsp. bulgaricus when incubated in milk supplemented with adenine and guanine. The L. delbrueckii subsp. bulgaricus-expressed proteome in milk changed upon incubation at 4°C for 5 days and included increased levels of 17 proteins, several of which confer functions in stress tolerance (AddB, UvrC, RecA, and DnaJ). However, even with the activation of stress responses in either milk or MRS, L. delbrueckii subsp. bulgaricus did not survive passage through the murine digestive tract. These findings inform efforts to understand how L. delbrueckii subsp. bulgaricus is adapted to the dairy environment and its implications for its health-benefiting properties in the human digestive tract. IMPORTANCELactobacillus delbrueckii subsp. bulgaricus has a long history of use in yogurt production. Although commonly cocultured with Streptococcus salivarius subsp. thermophilus in milk, fundamental knowledge of the adaptive responses of L. delbrueckii subsp. bulgaricus to the dairy environment and the consequences of those responses on the use of L. delbrueckii subsp. bulgaricus as a probiotic remain to be elucidated. In this study, we identified proteins of L. delbrueckii subsp. bulgaricus LBB.B5 that are synthesized in higher quantities in milk at growth-conducive and non-growth-conductive (refrigeration) temperatures compared to laboratory culture medium and further examined whether those L. delbrueckii subsp. bulgaricus cultures were affected differently in their capacity to survive transit through the murine digestive tract. This work provides novel insight into how a major, food-adapted microbe responds to its primary habitat. Such knowledge can be applied to improve starter culture and yogurt production and to elucidate matrix effects on probiotic performance